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Tamoxifen is a drug that exhibits antiestrogenic effects and is used in antitumor therapy.
Tamoxifen begins to bind to estrogen receptors and interferes with the effects of estradiol. Thus, the development of the tumor process is slowed down. Following consumption of the tablets, the components of the drug are absorbed very quickly in the digestive tract.
Tamoxifen has an effect similar to that of estrogen, beneficially affecting the state of the endometrium of the uterus, the musculoskeletal system, and the level of cholesterol in the blood.
Tamoxifen is prescribed for the treatment of estrogen-dependent tumors of the breast and uterus, melanomas, prostate carcinomas, sarcomas, and some other types of neoplasms. Furthermore, this drug can be used for replacement therapy after removal of the ovaries or in the absence of ovulation.
Indications for the use of Tamoxifen include:
- Breast cancer in men
- Breast cancer (especially in women during menopause)
- Cancer of the ovaries and endometrium
- Oligospermia in men
- Prostate cancer in men
- Pituitary tumor
- As part of postoperative therapy designed to stabilize the hormonal background
- Soft tissue sarcoma
Administration of Tamoxifen
The dosage of this drug is individually selected by the attending doctor in each individual case depending on the scheme of antitumor therapy and the patient’s characteristics.
Only adults can use the medication. Usually, treatment with Tamoxifen takes a long time (at least three months to four months). Sometimes, the treatment is delayed for years.
Tamoxifen is produced in the form of tablets. First, a smaller dose is prescribed, which, after some time, is increased to the required dose.
Tamoxifen is not recommended for people with an individual intolerance and/or severe pathologies of hematopoiesis.
Doctors recommending this medication should also take extreme caution when using it to treat patients with diabetes mellitus and/or ophthalmic disorders.
It should be noted that women who are of childbearing age, up to the onset of menopause, should use contraceptive measures, without the use of hormonal contraceptives, when taking this medication. This is because therapy with Tamoxifen is dangerous for a pregnancy. This is also true for up to two months after the completion of therapy. Additionally, during this time, it is worth it to refrain from breastfeeding a baby.
The medication annotation indicates that the number of side effects is less than that of hormonal drugs, which are also used in the treatment of cancer.
However, effects such as hot flashes, bleeding, and/or itching may be present. These are caused by the antiestrogenic effect of the drug. There may also be general side effects such as dyspepsia, swelling, hair loss, and so on.