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Innovation regarding medicines for the treatment of erectile dysfunction has led to the creation of two-component drugs, such as Sildalis (RSM Enterprises). The action of the main components of Sildalis, sildenafil citrate and tadalafil, is aimed at enhancing the vasodilating effect of nitric oxide on the cavernous musculature of the penis, which contributes to the emergence and long-term maintenance of a persistent physiological erection. It should be specially noted that such a combination of active substances mutually strengthens their effect and is more advantageous than taking a mono-drug. Besides, the affordable price of Sildalis makes its purchase more profitable.
One tablet of the drug contains 100 mg of sildenafil and 20 mg of tadalafil. Thus, when buying Sildalis, one will get two high-quality drugs at a very affordable price. The drug is to be taken 30 minutes to 40 minutes before the alleged sexual intercourse occurs. The effect lasts for 36 hours. Before taking Sildalis, it is advisable not to eat fatty foods, since such causes a slowdown in the absorption of active ingredients into the blood. It is not recommended to combine the intake of the drug with the use of alcohol because of the risk of a sharp drop in blood pressure.
If a person is allergic to the components of the drug; has severe heart disease, severe renal or hepatic insufficiency, or epilepsy; or takes nitrates, then Sildalis is not suitable for them. The medication is also prohibited for use by individuals younger than the age of 18 years.
With the proper attention to all requirements for taking the drug, side effects are rarely observed and disappear quickly enough. There may be heartburn, reactions of hypersensitivity to the components of the drug, low blurred vision or a violation of color perception, transient headaches or dizziness, short-term reddening of the face, and lowering of blood pressure. However, as a rule, these effects do not require additional treatment and generally pass independently.
It is forbidden to combine the drug with the use of nitrates and nicorandil because of the danger of physical collapse. The combination of Sildalis with alpha-blockers can also cause the development of orthostatic hypotension. Users of Sildalis should avoid the simultaneous intake of the drug with ketoconazole, erythromycin, and itraconazole because of the risk of increased plasma concentrations of sildenafil and tadalafil. The medication is not recommended to be taken with grapefruit juice.