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Priligy is used to treat premature ejaculation among men aged 18 to 64 years. The active ingredient of the medicine is dapoxetine hydrochloride, which belongs to the group of medicines known as selective serotonin reuptake inhibitors. Each tablet contains 30 or 60 mg of dapoxetine.
Dapoxetine prevents serotonin from returning to presynaptic endings of the sympathetic nervous system and by reduction of its activity temporary delay the reflex, which is responsible for ejaculation.
After ingestion, the drug is absorbed from the digestive tract and enters the systemic circulation. The maximum concentration is reached in 1-1.5 hours after intake.
Numerous clinical trials indicate the efficacy and safety of Priligy in the treatment of premature ejaculation, increasing the average duration of sexual intercourse from 50 seconds to 3.5 minutes.
Besides, the results of studies have shown that dapoxetine reduces personal stress and interpersonal difficulties associated with premature ejaculation and increases their control over ejaculation. One of these studies involved 1238 men with premature ejaculation aged 18 years and older from the United States and Canada and lasted for nine weeks. [Kaufman J.M., Rosen R.C., Mudumbi R.V., Tesfaye F., Hashmonay R., Rivas D. Treatment benefit of dapoxetine for premature ejaculation: results from a placebo-controlled phase III trial 2009.] Except for the effects mentioned above the study confirmed the safety of dapoxetine and its good tolerability.
The initial dosage of Priligy is 30 mg per day. The drug should be taken once a day, at least one hour before sexual intercourse (3 hours maximum).
Dapoxetine increases cardiac loads, so it is undesirable to take the medication in the case of cardiovascular diseases or liver pathologies. The most frequent side effects of Priligy include nausea, diarrhea, headache, dizziness, and drowsiness.
Priligy is not recommended for patients with allergic reactions to the components of the drug. Also, the drug is contraindicated in cases of epilepsy, hypotension, and problems with the functioning of the central nervous system.