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Clomid (Clomiphene) is a hormonal drug that is prescribed to women and is also in use among men who want to build up the muscles of the body.

The active substance of the drug is Clomiphene Citrate. Each tablet contains 50 mg of the active ingredient.

Pharmacological effect

Clomiphene has a hormonal effect on the patient’s body. Being a synthetic estrogen, it works as an anti-estrogen.

A key fact is that the active component of the tablets does not bind to the estradiol receptors. As a result, it does not cause the problems of drugs that affect the level of natural estrogens.

Indications for usage of the drug include:

  • Infertility caused by anovulatory cycles (to stimulate the maturation of follicles)
  • Spontaneous uterine bleeding
  • Absence of menstruation
  • The appearance of milk in the mammary glands not associated with the process of breastfeeding
  • Androgenic failure
  • Ovarian enlargement due to the formation of multiple cysts (i.e., polycystic ovary syndrome)
  • Oligospermia in men
  • Study of the causes of gonadotropic pituitary gland disorders

When taken in large amounts, Clomiphene has an antiestrogenic effect in that it inhibits the secretory activity of gonadotropins.

After consumption, the drug is quickly absorbed into the bloodstream, has a prolonged effect, and excreted after one week.

Dosage

Clomiphene instructions for use are given specifically for oral use. The standard dosage of the drug is in the form of one 50 mg tablet.

If the medicine is used once a day, then it should ideally be taken before bedtime without grinding or chewing.

Pregnancy and breastfeeding

Pregnancy and conception are one of the goals pursued by Clomiphene; however, with a confirmed pregnancy, it should not be taken.

Before a patient begins treatment suing Clomiphene, they must make sure that there is no pregnancy present.

During lactation, antiestrogens are not used. The medicine is able to penetrate into breast milk and will reach the child.

Contraindications

The list of contraindications for the use of Clomiphene is short; the drug should not be used in conjunction with the following:

  • Hypersensitivity to the active substance
  • Insufficiency of the liver and kidneys
  • Ovarian tumor
  • Bleeding from the genital tract of unclear etiology
  • Pituitary tumor
  • Pituitary insufficiency
  • Endometriosis
  • Increased level of prolactin in combination with insufficiency of the gonads
  • Possibility of blood clots
  • Pregnancy

Side effects

Most patients who use this medicine as prescribed by the doctor tolerate it well.

However, side effects can develop against a background of an overdose, in combination with alcohol, or from the use of the drug in the presence of contraindications.

The medicine affects the nervous system then provokes the inhibition of reactions, headaches, and drowsiness.

The possibility of dyspeptic disorders presenting will be lower if the medication is taken before bed.

In the daytime, its use can cause nausea and vomiting. Allergic reactions can develop with intolerance to the active substance and require urgent discontinuation of the drug.