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Azithromycin is one of the most popular antibacterial drugs available on the market today. It is used to treat various bacterial infections, primarily associated with respiratory organs. Azithromycin is an organic substance belonging to the group of macrolides, a subclass of azalides. This antibiotic blocks the production of certain vitally important proteins associated with bacteria, which causes them to stop growth and reproduction. Thus, Azithromycin demonstrates bacteriostatic as opposed to bactericidal action. However, in large dosages, Azithromycin takes on bactericidal properties.
Azithromycin causes a much smaller number of side effects associated with the gastrointestinal tract compared with other similar drugs.
Another useful property of this drug is the long withdrawal time from the body. This parameter is much higher than that for other antibiotics. This means that Azithromycin persists in the body for long periods of time. Often times, this drug can exert its effects 5-7 days after the end of the course of therapy. This drug property is very important during the treatment of severe and protracted infections which demonstrate a high probability of relapse.
Azithromycin demonstrates a wide spectrum of action and takes action against various types of bacteria including gram-negative, gram-positive, aerobes, and anaerobes. Only very few bacilli demonstrate resistance to this drug such as some strains of streptococci and staphylococci, salmonella, and shigella.
Azithromycin is used to treat infectious diseases affecting:
- upper respiratory tract (throat, nasopharynx, sinuses), lower respiratory tract (bronchi and trachea), lungs, genitourinary organs, skin.
- the respiratory system: obronchitis, pneumonia, pharyngitis, rhinitis, sinusitis, scarlet fever, otitis media, sinusitis.
- the urogenital organs: ourethritis, cervicitis, cystitis, adnexitis, prostatitis.
Azithromycin can also be used in the early stages of treating Lyme disease, various skin infections, and soft tissue infections (e.g., erysipelas, impetigo, dermatitis, moderate eels).
This drug can be produced in various dosage forms: film-coated tablets, absorbable tablets, capsules, suspension for children, and/or powder for the preparation of a solution for parenteral administration. However, most often this drug is dispensed in the form of tablets and capsules. In this dosage form, this drug contains 125, 250, 500 mg of the active ingredient.
Azithromycin also has some contraindications. First, it is necessary to prescribe this drug under extreme caution to women during pregnancy.
The drug in the form of intravenous administration should not be deployed to children. Also, tablet use is contraindicated for children under 12 years of age. Suspension administration should not be prescribed for children under 6 months and with weight less than 5 kg.
Side effects when taking Azithromycin are rare. Nevertheless, side effects are possible. The most common side effects when taking this drug are associated with the gastrointestinal tract involving pain in the stomach and stomach, diarrhea, nausea, constipation, and sometimes vomiting. It is important to remember that, similar to any other antibiotic, Azithromycin can affect the normal intestinal microflora, which can be expressed in dysbacteriosis.